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Literature summary for 3.1.1.118 extracted from
- DDHD1, but not DDHD2, suppresses neurite outgrowth in SH-SY5Y and PC12 cells by regulating protein transport from recycling endosomes (2020), Front. Cell Dev. Biol., 8, 670 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q3ZAU5 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| PC-12 cell | - |
Rattus norvegicus | - |
| SH-SY5Y cell | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDHD1 | - |
Rattus norvegicus |
| PA-PLA1 | - |
Rattus norvegicus |
| PA-preferring phospholipase A1 | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme depletion causes enlargement of early endosomes and stimulated tabulation of recycling endosomes positive for phosphatidic acid-binding proteins syndapin2 and MICAL-L1. Enzyme knockout enhances transferrin recycling from recycling endosomes to the cell surface | Rattus norvegicus |
| physiological function | the activity of the enzyme is necessary for the prevention of neurite elongation. The enzyme negatively controls the formation of a local phosphatidic acid-rich domain in recycling endosomes that serves as a membrane source for neurite outgrowth | Rattus norvegicus |
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Release 2023.1 (January 2023)
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